منابع مشابه
Effective interactions between charged dendrimers
We perform monomer-resolved computer simulations of fourth-generation charged dendrimers at various conditions of charging (full, terminal and neutral) and for different values of the spacer length P connecting the branching nodes, fromP1⁄4 1 toP1⁄4 6.We examine the sizes, overlaps and effective forces between the centers ofmass of the dendrimers with andwithout addedmonovalent and divalent sal...
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Dendrimers are nano-sized, radially symmetric molecules with well-defined, homogeneous and monodisperse structure consisting of tree-like arms or branches. Over the past two decades since the term ‘‘dendrimer’’ was formally defined, research interest in these molecules has gradually evolved from a primary focus on overcoming purely synthetic challenges to include aesthetic and theoretical persp...
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Ovarian cancer is the most lethal gynecological malignancy. Current treatment modalities include a combination of surgery and chemotherapy, which often lead to loss of fertility in premenopausal women and a myriad of systemic side effects. To address these issues, we have designed poly(amidoamine) (PAMAM) dendrimers to selectively target the follicle stimulating hormone receptor (FSHR), which i...
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The oncolytic viruses that were discovered in the late of 19th century have been recently considered as an effective anti-cancer therapy due to its selective replication activity in cancer cells. Currently, at least nine types of virus have been studied in clinical trials for treating a variety of cancers including T-VEC and Reolysin. In this review, we focus on historical researches of oncolyt...
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We demonstrate that pancreatic cancer tissues express receptors for interleukin (IL)-4 in situ at high density. Using the approach of selective receptor targeting, we have tested the efficacy of a recombinant cytotoxin IL4-Pseudomonas exotoxin A, which is composed of a targeting moiety (IL-4) and a mutated form of Pseudomonas exotoxin. Our results demonstrate that this molecule exerts vigorous ...
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ژورنال
عنوان ژورنال: Materials Today
سال: 2005
ISSN: 1369-7021
DOI: 10.1016/s1369-7021(05)71021-x